Structure of PDB 6z8v Chain H Binding Site BS02

Receptor Information
>6z8v Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FG
Ligand information
Receptor-Ligand Complex Structure
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PDB6z8v Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12.
Resolution1.58 Å
Binding residue
(original residue number in PDB)		I24 R75 Y76 E77 R77A N78 I79 Y117
Binding residue
(residue number reindexed from 1)		I9 R70 Y71 E72 R73 N74 I75 Y114
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z8v, PDBe:6z8v, PDBj:6z8v
PDBsum6z8v
PubMed33614235
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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