Structure of PDB 6v4x Chain H Binding Site BS02

Receptor Information
>6v4x Chain H (length=499) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDL
IDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLS
DYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGH
VLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYG
THIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQ
NHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHI
SNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYC
VEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRA
LKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNF
RGEKLAKVMGFLADGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6v4x Chain H Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v4x Structure of an active human histone pre-mRNA 3'-end processing machinery.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H71 H73 H158 D179
Binding residue
(residue number reindexed from 1)		H63 H65 H150 D171
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004534 5'-3' RNA exonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage
GO:0031124 mRNA 3'-end processing
GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6v4x, PDBe:6v4x, PDBj:6v4x
PDBsum6v4x
PubMed32029631
UniProtQ9UKF6|CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (Gene Name=CPSF3)

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