Structure of PDB 6ux4 Chain H Binding Site BS02

Receptor Information

>6ux4 Chain H (length=222) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SRHVVICGWSESTLECLRELRGSEVFVLAEDENVRKKVLRSGANFVHGDP
TRVSDLEKANVRGARAVIVDLESDSETIHCILGIRKIDESVRIIAEAERY
ENIEQLRMAGADQVISPFVISGRLMSRSIDDGYEAMFVQDVLAEESTRRM
VEVPIPEGSKLEGVSVLDADIHDVTGVIIIGVGRGDELIIDPPRDYSFRA
GDIILGIGKPEEIERLKNYISA

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6ux4 Chain D Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	6ux4 Ball-and-chain inactivation in a calcium-gated potassium channel.
Resolution	3.5 Å
Binding residue (original residue number in PDB)	R241 E248
Binding residue (residue number reindexed from 1)	R127 E134
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0008324	monoatomic cation transmembrane transporter activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0006813	potassium ion transport
GO:0034220	monoatomic ion transmembrane transport
GO:0098655	monoatomic cation transmembrane transport

	Cellular Component
GO:0005886	plasma membrane

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6ux4, PDBe:6ux4, PDBj:6ux4
PDBsum	6ux4
PubMed	32269335
UniProt	O27564\|MTHK_METTH Calcium-gated potassium channel MthK (Gene Name=mthK)

[Back to BioLiP]