Structure of PDB 6t57 Chain H Binding Site BS02

Receptor Information
>6t57 Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
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PDB6t57 Thrombin in Complex with a D-Phe-Pro-N-amidinopiperidine Derivative
Resolution1.57 Å
Binding residue
(original residue number in PDB)		F34 L40 R67 T74 R75 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F19 L26 R62 T69 R70 Y71 K77 I78
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E194 G195 D196 S197 G198
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:6t57, PDBe:6t57, PDBj:6t57
PDBsum6t57
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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