Structure of PDB 6n7w Chain H Binding Site BS02

Receptor Information
>6n7w Chain H (length=702) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFGAYLDALEAEV
ARGGLIVFHNGHKYDVPALTKLAKLQLNREFHLPRENCIDTLVLSRLIHS
NLKDTDMGLLRKLPGKRFGSHALEAWGYRLGEMKGEYKDDFKRMLEEQGE
EYVDGMEWWNFNEEMMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVG
YTTFWSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVELAARRSE
LLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKYPRIKTPKVGGIFKKPK
NKAQREGREPCELDTREYVAGAPYTPVEHVVFNPSSRDHIQKKLQEAGWV
PTKYTDKGAPVVDDEVLEGVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEG
DKAWLRYVAEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCR
AAFGAEHHLDGITGKPWVQAGIDASGLELRCLAHFMARFDNGEYAHEILN
GDIHTKNQIAAELPTRDNAKTFIYGFLYGAGDEKIGQIVGAGKERGKELK
KKFLENTPAIAALRESIQQTLVESSQWVAGEQQVKWKRRWIKGLDGRKVH
VRSPHAALNTLLQSAGALICKLWIIKTEEMLVEKGLKHGWDGDFAYMAWV
HDEIQVGCRTEEIAQVVIETAQEAMRWVGDHWNFRCLLDTEGKMGPNWAI
CH
Ligand information
>6n7w Chain T (length=45) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acggagtcgcgactccgttatcacgctatgtcgtcaagttgtacc
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6n7w Structures and operating principles of the replisome.
Resolution4.5 Å
Binding residue
(original residue number in PDB)		N335 S338 A425 F434 N436 Q439 T523 Y526 G527 Y530 A532 G533 K536 W579 A581 R604 H607 N611
Binding residue
(residue number reindexed from 1)		N333 S336 A423 F432 N434 Q437 T521 Y524 G525 Y528 A530 G531 K534 W577 A579 R602 H605 N609
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004527 exonuclease activity
GO:0004529 DNA exonuclease activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006302 double-strand break repair
GO:0039693 viral DNA genome replication
GO:0090592 DNA synthesis involved in DNA replication

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6n7w, PDBe:6n7w, PDBj:6n7w
PDBsum6n7w
PubMed30679383
UniProtP00581|DPOL_BPT7 DNA-directed DNA polymerase (Gene Name=5)

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