Structure of PDB 6erf Chain H Binding Site BS02

Receptor Information

>6erf Chain H (length=526) Species: 9606 (Homo sapiens)

NKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIA
LVLFGTDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQA
DFLDALIVSMDVIQHETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLK
KCDISLQFFLPFSLGPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLE
GEDGLDEIYSFSESLRKLCVFKKIERHSIHWPCRLTIGSNLSIRIAAYKS
ILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDDDETEVLKEDIIQGFRY
GSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQVLKVFA
ARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNY
ECLVYVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKK
DEKTDTLEDLFPTTKIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNML
NPPAEVTTKSQIPLSKIKTLFPLIEA

Ligand information

>6erf Chain P (length=16)

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 6erf XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
• Resolution: 3.01 Å
• Binding residue (original residue number in PDB): I245 K265 K291 Y397 N402
• Binding residue (residue number reindexed from 1): I229 K249 K275 Y381 N386

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0003684 damaged DNA binding
• GO:0042162 telomeric DNA binding

Biological Process

• GO:0000723 telomere maintenance
• GO:0006303 double-strand break repair via nonhomologous end joining
• GO:0006310 DNA recombination

Cellular Component

• GO:0005634 nucleus
• GO:0043564 Ku70:Ku80 complex

External links

• PDB: RCSB:6erf, PDBe:6erf, PDBj:6erf
• PDBsum: 6erf
• PubMed: 30291363
• UniProt: P13010|XRCC5_HUMAN X-ray repair cross-complementing protein 5 (Gene Name=XRCC5)