Structure of PDB 5weh Chain H Binding Site BS02

Receptor Information

>5weh Chain H (length=253) Species: 1063 (Cereibacter sphaeroides)

LEIIGRPQPGGTGFQPSASPVATQIHWLDGFILVIIAAITIFVTLLILYA
VWRFHEKRNKVPARFTHNSPLEIAWTIVPIVILVAIGAFSLPVLFNQQEI
PEADVTVKVTGYQWYWGYEYPDEEISFESYMIGSPATGGDNRMSPEVEQQ
LIEAGYSRDEFLLATDTAMVVPVNKTVVVQVTGADVIHSWTVPAFGVKQD
AVPGRLAQLWFRAEREGIFFGQCSELCGISHAYMPITVKVVSEEAYAAWL
EQH

Ligand information

• Ligand ID: CU1
• InChI: InChI=1S/Cu/q+1
• InChIKey: VMQMZMRVKUZKQL-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Cu+]
• Formula: Cu
• Name: COPPER (I) ION
• PDB chain: 5weh Chain H Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5weh Role of conformational change and K-path ligands in controlling cytochrome c oxidase activity.
• Resolution: 3.45 Å
• Binding residue (original residue number in PDB): C252 H260
• Binding residue (residue number reindexed from 1): C223 H231
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0005507 copper ion binding
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0022900 electron transport chain
• GO:0042773 ATP synthesis coupled electron transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5weh, PDBe:5weh, PDBj:5weh
• PDBsum: 5weh
• PubMed: 28842531
• UniProt: Q03736|COX2_CERSP Cytochrome c oxidase subunit 2 (Gene Name=ctaC)