Structure of PDB 5o32 Chain H Binding Site BS02

Receptor Information
>5o32 Chain H (length=301) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCVCKLPYQCPKNGTAVC
ATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGNTDSEG
IVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLS
INSTECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDD
FFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQ
YQCNGEVDCITGEDEVGCAGEETEILTADMDAERRRIKSLLPKLSCGVKN
R
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5o32 Chain H Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5o32 Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses.
Resolution4.20621 Å
Binding residue
(original residue number in PDB)		K239 A240 D242 I244 D246 D252 E253
Binding residue
(residue number reindexed from 1)		K214 A215 D217 I219 D221 D227 E228
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.45: complement factor I.
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:5o32, PDBe:5o32, PDBj:5o32
PDBsum5o32
PubMed28671664
UniProtP05156|CFAI_HUMAN Complement factor I (Gene Name=CFI)

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