Structure of PDB 5nhu Chain H Binding Site BS02

Receptor Information
>5nhu Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FG
Ligand information
>5nhu Chain I (length=24) Species: 7165 (Anopheles gambiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EFDPSLLADAPTARDPGRNPEFLR
Receptor-Ligand Complex Structure
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PDB5nhu Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		Q344 E345 L346 H363 Y367 W370 L380 R388 T389 Y391 K397 E414 N415 L416 K427 K474 Q476 I499 D519 A520 E522 G523 S525 W547 G548 E549 G550
Binding residue
(residue number reindexed from 1)		Q24 E25 L26 H43 Y47 W50 L60 R68 T69 Y71 K77 E94 N95 L96 K107 K148 Q150 I173 D193 A194 E196 G197 S199 W221 G222 E223 G224
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5nhu, PDBe:5nhu, PDBj:5nhu
PDBsum5nhu
PubMed28592490
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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