Structure of PDB 5mnj Chain H Binding Site BS02

Receptor Information
>5mnj Chain H (length=64) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPI
CKKEIQLVIKVFIA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5mnj Chain H Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mnj Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Resolution2.16 Å
Binding residue
(original residue number in PDB)		C437 C440 C460 C463
Binding residue
(residue number reindexed from 1)		C11 C14 C34 C37
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5mnj, PDBe:5mnj, PDBj:5mnj
PDBsum5mnj
PubMed28553961
UniProtO15151|MDM4_HUMAN Protein Mdm4 (Gene Name=MDM4)

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