Structure of PDB 5l6n Chain H Binding Site BS02

Receptor Information
>5l6n Chain H (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGKG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
QFGE
Ligand information
>5l6n Chain I (length=24) Species: 44386 (Haemaphysalis longicornis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DYDEYEEDGTTPTPDPTAPTAKPR
Receptor-Ligand Complex Structure
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PDB5l6n Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors.
Resolution1.627 Å
Binding residue
(original residue number in PDB)		H363 Y367 W370 H407 R409 R413 E414 R418 R443 R498 I499 N504 D519 A520 E522 S525 W547 F564 R565 L566 K568 K572
Binding residue
(residue number reindexed from 1)		H43 Y47 W50 H87 R89 R93 E94 R98 R123 R173 I174 N179 D194 A195 E197 S200 W222 F239 R240 L241 K243 K247
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5l6n, PDBe:5l6n, PDBj:5l6n
PDBsum5l6n
PubMed28837178
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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