Structure of PDB 5ew1 Chain H Binding Site BS02

Receptor Information
>5ew1 Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
Receptor-Ligand Complex Structure
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PDB5ew1 Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		Y89 H91 P92 R93 Y94 N95 W96 R97 R101 R126 L130 A132 I162 V163 R165 K169 D178 F181 H230 R233 W237 K240 F245
Binding residue
(residue number reindexed from 1)		Y85 H87 P88 R89 Y90 N91 W92 R93 R98 R123 L130 A132 I160 V161 R163 K167 D176 F179 H235 R238 W242 K245 F250
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ew1, PDBe:5ew1, PDBj:5ew1
PDBsum5ew1
PubMed27899589
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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