Structure of PDB 5afz Chain H Binding Site BS02
Receptor Information
>5afz Chain H (length=250) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>5afz Chain L (length=28) Species:
9606
(Homo sapiens) [
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EADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB
5afz
Fragments Can Bind Either More Enthalpy or Entropy-Driven: Crystal Structures and Residual Hydration Pattern Suggest Why.
Resolution
1.53 Å
Binding residue
(original residue number in PDB)
E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207
Binding residue
(residue number reindexed from 1)
E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 N210 R211 W212
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:5afz
,
PDBe:5afz
,
PDBj:5afz
PDBsum
5afz
PubMed
26270568
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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