Structure of PDB 3wtw Chain H Binding Site BS02
Receptor Information
>3wtw Chain H (length=101) Species:
9606
(Homo sapiens) [
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GPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKP
KMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAM
L
Ligand information
>3wtw Chain J (length=15) [
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agaggatgtggcttc
Receptor-Ligand Complex Structure
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PDB
3wtw
A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
Resolution
2.9 Å
Binding residue
(original residue number in PDB)
R391 R394 Y395 Y397 K404 R409
Binding residue
(residue number reindexed from 1)
R59 R62 Y63 Y65 K72 R77
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003700
DNA-binding transcription factor activity
GO:0043565
sequence-specific DNA binding
Biological Process
GO:0006355
regulation of DNA-templated transcription
GO:0006357
regulation of transcription by RNA polymerase II
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Molecular Function
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Biological Process
External links
PDB
RCSB:3wtw
,
PDBe:3wtw
,
PDBj:3wtw
PDBsum
3wtw
PubMed
25083921
UniProt
P14921
|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)
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