Structure of PDB 3vxf Chain H Binding Site BS02
Receptor Information
>3vxf Chain H (length=257) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
>3vxf Chain J (length=10) Species:
32644
(unidentified) [
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DFEEIPEEYL
Receptor-Ligand Complex Structure
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PDB
3vxf
Neutron and X-ray crystallographic analysis of the human alpha-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex
Resolution
1.602 Å
Binding residue
(original residue number in PDB)
F34 K36 L65 R73 T74 Y76 R77A I82
Binding residue
(residue number reindexed from 1)
F19 K21 L60 R68 T69 Y71 R73 I78
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
External links
PDB
RCSB:3vxf
,
PDBe:3vxf
,
PDBj:3vxf
PDBsum
3vxf
PubMed
23712263
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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