Structure of PDB 3utu Chain H Binding Site BS02

Receptor Information
>3utu Chain H (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWD
KNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIA
LMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3utu Beyond heparinization: design of highly potent thrombin inhibitors suitable for surface coupling
Resolution1.55 Å
Binding residue
(original residue number in PDB)		F34 L65 R67 R73 T74 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F18 L59 R61 R67 T68 Y70 K76 I77
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3utu, PDBe:3utu, PDBj:3utu
PDBsum3utu
PubMed22907907
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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