Structure of PDB 3u8r Chain H Binding Site BS02

Receptor Information
>3u8r Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
E
Ligand information
Receptor-Ligand Complex Structure
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PDB3u8r Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors.
Resolution1.47 Å
Binding residue
(original residue number in PDB)		H363 W370 N415 L416 I499 D519 A520 E522 S525 S546 W547 G548
Binding residue
(residue number reindexed from 1)		H43 W50 N95 L96 I171 D191 A192 E194 S197 S218 W219 G220
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3u8r, PDBe:3u8r, PDBj:3u8r
PDBsum3u8r
PubMed22457833
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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