Structure of PDB 3p6z Chain H Binding Site BS02

Receptor Information
>3p6z Chain H (length=255) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
GQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGD
SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
DQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3p6z Structural basis of thrombin-mediated factor V activation: the Glu666-Glu672 sequence is critical for processing at the heavy chain-B domain junction.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		F382 R431 T432 R433 Y434 R436
Binding residue
(residue number reindexed from 1)		F19 R68 T69 R70 Y71 R73
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3p6z, PDBe:3p6z, PDBj:3p6z
PDBsum3p6z
PubMed21555742
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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