Structure of PDB 3ijx Chain H Binding Site BS02

Receptor Information
>3ijx Chain H (length=258) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKNK
WWYDKGEC
Ligand information
Ligand IDHCZ
InChIInChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChIKeyJZUFKLXOESDKRF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0c1c2c(cc(c1Cl)S(=O)(=O)N)S(=O)(=O)NCN2
ACDLabs 11.02O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)NCN2)N
CACTVS 3.352N[S](=O)(=O)c1cc2c(NCN[S]2(=O)=O)cc1Cl
FormulaC7 H8 Cl N3 O4 S2
Name6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
ChEMBLCHEMBL435
DrugBankDB00999
ZINCZINC000000896569
PDB chain3ijx Chain H Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3ijx Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Resolution2.881 Å
Binding residue
(original residue number in PDB)		P105 S108 L239 S242
Binding residue
(residue number reindexed from 1)		P102 S105 L236 S239
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3ijx, PDBe:3ijx, PDBj:3ijx
PDBsum3ijx
PubMed19673491
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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