Structure of PDB 3hat Chain H Binding Site BS02

Receptor Information
>3hat Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
E
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3hat Active-site mimetic inhibition of thrombin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H57 Y60A W60D I174 D189 A190 S195 S214 W215 G216
Binding residue
(residue number reindexed from 1)		H43 Y47 W50 I171 D191 A192 S197 S218 W219 G220
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3hat, PDBe:3hat, PDBj:3hat
PDBsum3hat
PubMed15299843
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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