Structure of PDB 3gut Chain H Binding Site BS02

Receptor Information
>3gut Chain H (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKSYPQVKICNYV
GPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGVCTVTAGPKDMVVGFANLG
ILHVTKKKVFETLEARMTEACIRGYNPGLLVHSDLAYLQAEGGGDRQLTD
REKEIIRQAAVQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIY
DSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEEN
GGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLE
TSEPKPFLYYPE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3gut Structural basis of HIV-1 activation by NF-kappaB--a higher-order complex of p50:RelA bound to the HIV-1 LTR.
Resolution3.59 Å
Binding residue
(original residue number in PDB)		Y357 C359 E360 K444 K541 Q574 Q606
Binding residue
(residue number reindexed from 1)		Y19 C21 E22 K106 K203 Q236 Q268
Binding affinityPDBbind-CN: Kd=1.5nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3gut, PDBe:3gut, PDBj:3gut
PDBsum3gut
PubMed19683540
UniProtP19838|NFKB1_HUMAN Nuclear factor NF-kappa-B p105 subunit (Gene Name=NFKB1)

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