Structure of PDB 3f68 Chain H Binding Site BS02

Receptor Information
>3f68 Chain H (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
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PDB3f68 Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		F34 Q38 E39 L40 R73 T74 Y76 I82
Binding residue
(residue number reindexed from 1)		F19 Q24 E25 L26 R68 T69 Y71 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3f68, PDBe:3f68, PDBj:3f68
PDBsum3f68
PubMed19520086
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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