Structure of PDB 3dt0 Chain H Binding Site BS02

Receptor Information
>3dt0 Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3dt0 Understanding Thrombin Inhibition
Resolution2.4 Å
Binding residue
(original residue number in PDB)		F34 Q38 E39 L40 R67 R73 T74 R75 Y76 I82
Binding residue
(residue number reindexed from 1)		F19 Q24 E25 L26 R62 R68 T69 R70 Y71 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3dt0, PDBe:3dt0, PDBj:3dt0
PDBsum3dt0
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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