Structure of PDB 2zhf Chain H Binding Site BS02

Receptor Information
>2zhf Chain H (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2zhf Exploring thrombin S3 pocket
Resolution1.98 Å
Binding residue
(original residue number in PDB)		F34 Q38 L40 L65 R73 T74 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F19 Q24 L26 L60 R68 T69 Y71 K77 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2zhf, PDBe:2zhf, PDBj:2zhf
PDBsum2zhf
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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