Structure of PDB 2h9t Chain H Binding Site BS02

Receptor Information
>2h9t Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
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PDB2h9t Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H57 Y60A N98 L99 D189 A190 C191 G193 S195 S214 W215 G216
Binding residue
(residue number reindexed from 1)		H43 Y47 N95 L96 D190 A191 C192 G194 S196 S217 W218 G219
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2h9t, PDBe:2h9t, PDBj:2h9t
PDBsum2h9t
PubMed19332154
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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