Structure of PDB 2gde Chain H Binding Site BS02

Receptor Information
>2gde Chain H (length=249) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2gde Total synthesis and structural confirmation of chlorodysinosin A.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		K36 Q38 E39 L40 L65 R67 R73 T74 R75 Y76 I82
Binding residue
(residue number reindexed from 1)		K21 Q24 E25 L26 L60 R62 R68 T69 R70 Y71 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2gde, PDBe:2gde, PDBj:2gde
PDBsum2gde
PubMed16895415
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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