Structure of PDB 2bxu Chain H Binding Site BS02

Receptor Information
>2bxu Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
>2bxu Chain L (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB2bxu Design and Discovery of Novel, Potent Pyrazinone-Based Thrombin Inhibitors with a Solubilizing P1-P2-Linker
Resolution2.8 Å
Binding residue
(original residue number in PDB)		E23 M26 P28 W29 D116 H119 P120 V121 C122 Y134 K135 G136 R137 N159 M201 K202 P204 R206 W207
Binding residue
(residue number reindexed from 1)		E8 M11 P13 W14 D113 H116 P117 V118 C119 Y134 K135 G136 R137 N158 M205 K206 P208 R212 W213
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:2bxu, PDBe:2bxu, PDBj:2bxu
PDBsum2bxu
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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