Structure of PDB 1ypl Chain H Binding Site BS02

Receptor Information
>1ypl Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB1ypl Design and X-ray crystal structures of human thrombin with synthetic cyanopeptide-analogues.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		F34 R67 R73 T74 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F19 R62 R68 T69 Y71 K77 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ypl, PDBe:1ypl, PDBj:1ypl
PDBsum1ypl
PubMed17341023
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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