Structure of PDB 1tmt Chain H Binding Site BS02

Receptor Information
>1tmt Chain H (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1tmt Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H57 Y60A N98 L99 D189 A190 S195 W215 G216 F245
Binding residue
(residue number reindexed from 1)		H43 Y47 N95 L96 D199 A200 S205 W227 G228 F257
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1tmt, PDBe:1tmt, PDBj:1tmt
PDBsum1tmt
PubMed8251938
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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