Structure of PDB 1qur Chain H Binding Site BS02

Receptor Information
>1qur Chain H (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF
Ligand information
Receptor-Ligand Complex Structure
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PDB1qur Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		F34 P37 Q38 E39 L40 H57 Y60A W60D R73 T74 R75 I82 M84 N98 K110 I174 D189 A190 E192 W215 G216 G219
Binding residue
(residue number reindexed from 1)		F19 P23 Q24 E25 L26 H43 Y47 W50 R68 T69 R70 I78 M80 N95 K107 I179 D199 A200 E202 W227 G228 G230
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1qur, PDBe:1qur, PDBj:1qur
PDBsum1qur
PubMed10504391
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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