Structure of PDB 1p8j Chain H Binding Site BS02

Receptor Information
>1p8j Chain H (length=466) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YQEPTDPKFPQQWYLSGVTQRDLNVKEAWAQGFTGHGIVVSILDDGIEKN
HPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNG
VCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDD
GKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT
NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQK
CTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNAD
DWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIVEILVEPK
DIGKRLEVRKAVTACLGEPNHITRLEHVQARLTLSYNRRGDLAIHLISPM
GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPAGEWVLEIENTSEANN
YGTLTKFTLVLYGTAP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1p8j The Crystal Structure of the Proprotein Processing Proteinase Furin Explains its Stringent Specificity
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D154 H194 E236 S253 W254 G255 P256 D258 D264 G294 N295 D306 Y308 S368
Binding residue
(residue number reindexed from 1)		D45 H85 E127 S144 W145 G146 P147 D149 D155 G185 N186 D197 Y199 S259
Enzymatic activity
Catalytic site (original residue number in PDB) D153 H194
Catalytic site (residue number reindexed from 1) D44 H85
Enzyme Commision number 3.4.21.75: furin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1p8j, PDBe:1p8j, PDBj:1p8j
PDBsum1p8j
PubMed12794637
UniProtP23188|FURIN_MOUSE Furin (Gene Name=Furin)

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