Structure of PDB 1nzq Chain H Binding Site BS02
Receptor Information
>1nzq Chain H (length=250) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
Ligand information
>1nzq Chain D (length=11) [
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uYEPIPEEFAQ
Receptor-Ligand Complex Structure
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PDB
1nzq
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety
Resolution
2.18 Å
Binding residue
(original residue number in PDB)
Q38 L40 R67 R73 T74 R75 Y76 I82
Binding residue
(residue number reindexed from 1)
Q24 L26 R62 R68 T69 R70 Y71 I78
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1nzq
,
PDBe:1nzq
,
PDBj:1nzq
PDBsum
1nzq
PubMed
12781189
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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