Structure of PDB 1nrq Chain H Binding Site BS02

Receptor Information
>1nrq Chain H (length=242) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
Ligand information
Receptor-Ligand Complex Structure
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PDB1nrq Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		H57 W60D L99 I174
Binding residue
(residue number reindexed from 1)		H43 W50 L96 I171
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrq, PDBe:1nrq, PDBj:1nrq
PDBsum1nrq
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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