Structure of PDB 1nrp Chain H Binding Site BS02

Receptor Information
>1nrp Chain H (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
VGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDAC
EGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
KVIDQFG
Ligand information
Receptor-Ligand Complex Structure
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PDB1nrp Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		H57 W60D L99 S195 S214 G216 G219
Binding residue
(residue number reindexed from 1)		H43 W50 L96 S204 S225 G227 G229
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1nrp, PDBe:1nrp, PDBj:1nrp
PDBsum1nrp
PubMed8136362
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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