Structure of PDB 1k22 Chain H Binding Site BS02

Receptor Information
>1k22 Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
Receptor-Ligand Complex Structure
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PDB1k22 Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
Resolution1.93 Å
Binding residue
(original residue number in PDB)		Q38 R73 T74 R75 Y76 K81 I82 M84
Binding residue
(residue number reindexed from 1)		Q24 R68 T69 R70 Y71 K77 I78 M80
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1k22, PDBe:1k22, PDBj:1k22
PDBsum1k22
PubMed11676542
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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