Structure of PDB 1ihs Chain H Binding Site BS02

Receptor Information
>1ihs Chain H (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG
Ligand information
>1ihs Chain I (length=19) Species: 6421 (Hirudo medicinalis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FPRQSHNDGDFEEIPEEYL
Receptor-Ligand Complex Structure
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PDB1ihs Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q38 L40 L41 H57 Y60A K60F L65 R67 R73 T74 R75 Y76 N98 A149A V149C D189 E192 S195 W215 G216 G246
Binding residue
(residue number reindexed from 1)		Q24 L26 L27 H43 Y47 K52 L60 R62 R68 T69 R70 Y71 N95 A150 V152 D199 E202 S205 W227 G228 G258
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ihs, PDBe:1ihs, PDBj:1ihs
PDBsum1ihs
PubMed8272424
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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