Structure of PDB 1hxf Chain H Binding Site BS02

Receptor Information
>1hxf Chain H (length=248) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1hxf The molecular environment of the Na+ binding site of thrombin.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		F34 K36 R73 T74 Y76 I82
Binding residue
(residue number reindexed from 1)		F19 K21 R68 T69 Y71 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hxf, PDBe:1hxf, PDBj:1hxf
PDBsum1hxf
PubMed9108691
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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