Structure of PDB 1hlt Chain H Binding Site BS02

Receptor Information
>1hlt Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTG
QPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDS
GGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID
Q
Ligand information
Receptor-Ligand Complex Structure
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PDB1hlt Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		F34 Q38 L65 R67 T74 Y76 R77A I82
Binding residue
(residue number reindexed from 1)		F19 Q24 L60 R62 T69 Y71 R73 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1hlt, PDBe:1hlt, PDBj:1hlt
PDBsum1hlt
PubMed7947765
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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