Structure of PDB 1fph Chain H Binding Site BS02

Receptor Information
>1fph Chain H (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1fph The interaction of thrombin with fibrinogen. A structural basis for its specificity.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H57 Y60A W60D R97 E97A L99 R173 I174 D189 A190 S195 S214 W215 G216
Binding residue
(residue number reindexed from 1)		H43 Y47 W50 R93 E94 L96 R178 I179 D199 A200 S205 S226 W227 G228
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1fph, PDBe:1fph, PDBj:1fph
PDBsum1fph
PubMed1587268
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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