Structure of PDB 1dit Chain H Binding Site BS02

Receptor Information
>1dit Chain H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
E
Ligand information
Receptor-Ligand Complex Structure
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PDB1dit Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		F34 P37 Q38 E39 L40 H57 Y60A K60F R73 T74 Y76 N98 Q151 D189 A190 C191 G193 S195 W215 G216 E217 G219
Binding residue
(residue number reindexed from 1)		F19 P23 Q24 E25 L26 H43 Y47 K52 R68 T69 Y71 N95 Q148 D191 A192 C193 G195 S197 W219 G220 E221 G222
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1dit, PDBe:1dit, PDBj:1dit
PDBsum1dit
PubMed8868478
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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