Structure of PDB 1b5g Chain H Binding Site BS02

Receptor Information
>1b5g Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1b5g Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
Resolution2.07 Å
Binding residue
(original residue number in PDB)		K36 Q38 L65 R73 T74 Y76 K81 I82 M84
Binding residue
(residue number reindexed from 1)		K21 Q24 L60 R68 T69 Y71 K77 I78 M80
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1b5g, PDBe:1b5g, PDBj:1b5g
PDBsum1b5g
PubMed10212123
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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