Structure of PDB 1awf Chain H Binding Site BS02

Receptor Information

>1awf Chain H (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG

Ligand information

>1awf Chain I (length=10) Species: 6421 (Hirudo medicinalis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DFEEIPEEYL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1awf Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	F34 L65 R73 T74 R75 Y76 K81 I82 M84
Binding residue (residue number reindexed from 1)	F19 L60 R68 T69 R70 Y71 K77 I78 M80

Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

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Molecular Function

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Biological Process

External links

PDB	RCSB:1awf, PDBe:1awf, PDBj:1awf
PDBsum	1awf
PubMed	9578548
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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