Structure of PDB 1aht Chain H Binding Site BS02
Receptor Information
>1aht Chain H (length=251) Species:
9606
(Homo sapiens) [
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IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G
Ligand information
>1aht Chain I (length=10) Species:
6421
(Hirudo medicinalis) [
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DFEEIPEEYL
Receptor-Ligand Complex Structure
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PDB
1aht
Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.
Resolution
1.6 Å
Binding residue
(original residue number in PDB)
L65 R67 R73 T74 R75 Y76 K81 I82 M84
Binding residue
(residue number reindexed from 1)
L60 R62 R68 T69 R70 Y71 K77 I78 M80
Enzymatic activity
Enzyme Commision number
3.4.21.5
: thrombin.
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005509
calcium ion binding
Biological Process
GO:0006508
proteolysis
GO:0007596
blood coagulation
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Molecular Function
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Biological Process
External links
PDB
RCSB:1aht
,
PDBe:1aht
,
PDBj:1aht
PDBsum
1aht
PubMed
7574675
UniProt
P00734
|THRB_HUMAN Prothrombin (Gene Name=F2)
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