Structure of PDB 1a5g Chain H Binding Site BS02

Receptor Information
>1a5g Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
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PDB1a5g Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
Resolution2.06 Å
Binding residue
(original residue number in PDB)		F34 L65 R67 T74 Y76 K81 I82
Binding residue
(residue number reindexed from 1)		F19 L60 R62 T69 Y71 K77 I78
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1a5g, PDBe:1a5g, PDBj:1a5g
PDBsum1a5g
PubMed10212123
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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