Structure of PDB 1a2c Chain H Binding Site BS02

Receptor Information
>1a2c Chain H (length=252) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
GE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1a2c The Structure of a Complex of Recombinant Hirudin and Human Alpha-Thrombin
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y60A W60D D189 C191 S195 W215 G216 E217 G219 R221A
Binding residue
(residue number reindexed from 1)		Y47 W50 D192 C194 S198 W220 G221 E222 G223 R226
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1a2c, PDBe:1a2c, PDBj:1a2c
PDBsum1a2c
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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