Structure of PDB 5it7 Chain GG Binding Site BS02

Receptor Information

>5it7 Chain GG (length=233) Species: 28985 (Kluyveromyces lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NPLTKSSPRNFGIGQAIQPKRNLSRYVKWPEYVRLQRQKKILSIRLKVPP
SIAQFQNTLDRNTAAETFKLLKKYSPETAAEKKERLTKEAAAIAEGKTKQ
EASPKPYVVKYGLNHVVSLIENKKAKLVLIANDVDPIELVIFLPALCKKM
GVPYAIVKGKARLGTLVNQKTSAVAALTEVREEDEAALAKLVSTINANYL
EKYEDSKKHWGGGIMGQKAQKKIEKRAKAAESA

Ligand information

>5it7 Chain 8 (length=157) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagc
gaauugcgauauguauugugaauugcagauuuucgugaaucaucaaaucu
uugaacgcacauugcgcccucugguauuccagggggcaugccuguuugag
cgucauu

.........................................<<<<<<<((
....>>>>.....<..<<......))..............>>...>...>
>>....<<.....>><<<<<<<<<....>>>>>>>>>.............
.......

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5it7 Structural characterization of ribosome recruitment and translocation by type IV IRES.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	W51 Y54 V55 Q58 R59 K62 R184
Binding residue (residue number reindexed from 1)	W29 Y32 V33 Q36 R37 K40 R162

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding

	Biological Process
GO:0000470	maturation of LSU-rRNA
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:5it7, PDBe:5it7, PDBj:5it7
PDBsum	5it7
PubMed	27159451
UniProt	B4UN96

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