Structure of PDB 8r08 Chain G Binding Site BS02

Receptor Information
>8r08 Chain G (length=579) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRDKSK
ELHAIKERYLRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDL
KQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQ
KKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKC
GYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKI
DRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISRE
DQGFRLRMGEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFE
PDVQKILEHMPVSNQKPDTDEAEPEKMLANFESGKHKYRQTVMFTATMPP
AVERLARSYLRRPAVVYIGKPHERVEQKVFLMSESEKRKKLLAILEQGFD
PPIIIFVNQKKGCDVLAKSLEKMGYNACTLREFALSNLKAGAKDILVATD
VIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVF
YELKQAILESPVSSPPELANHPDAQHKPG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution6.1 Å
Binding residue
(original residue number in PDB)		P476 T477 R478 I503 G504 G505 S507 T525 G527 R528 D531 M557 V723
Binding residue
(residue number reindexed from 1)		P267 T268 R269 I294 G295 G296 S298 T315 G317 R318 D321 M347 V501
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000354 cis assembly of pre-catalytic spliceosome
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0062176 R-loop processing
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070062 extracellular exosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtQ9BUQ8|DDX23_HUMAN Probable ATP-dependent RNA helicase DDX23 (Gene Name=DDX23)

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