Structure of PDB 8ovj Chain G Binding Site BS02

Receptor Information

>8ovj Chain G (length=226) Species: 347515 (Leishmania major strain Friedlin)

HFAARPKNFGIGQDVPYARDLSRFMRWPTFVTMQRKKRVLQRRLKVPPAL
NQFTKVLDRASRNEALKLIKKYAPETRKARRERLQKVAEKAPLAVVTGLQ
EVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRANKIPYAIVKDMARLG
DAIGRKTATCVALTDVNAEDEATLKNLIRSVNARFLSRSDVIRRQWGGLQ
LSLRSRAELRKKHARNAGVDAAAIIQ

Ligand information

>8ovj Chain 7 (length=164)

aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagu
aaagugcgauaagugguaucaauugcagaacauucaauuaccgaaucuuu
gaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccau
auucucagugucga

.........................................<<<<<<.((
.....>>>.....<<<<<......))............>>>>.>...>>>
....<<.....>><<<<<<<....<<....>>....>>>>>>>.......
..............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ovj Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): R49 Q60 R61 R88 K182 D183 R186
• Binding residue (residue number reindexed from 1): R23 Q34 R35 R62 K144 D145 R148

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ovj, PDBe:8ovj, PDBj:8ovj
• PDBsum: 8ovj
• PubMed: 38722744
• UniProt: Q4QIP1