Structure of PDB 7zi4 Chain G Binding Site BS02

Receptor Information
>7zi4 Chain G (length=682) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIW
GPFLIISPASTLNNWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSAPFH
VVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQCRN
RLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWENQLSRLHMILKP
FMLRRIKKDVENELSDKIEILMYCQLTSRQKLLYQALKNLVMQFRKVCNH
PELFERQETWSPFHISLKPYHISKFIYRHGQIRVFNHSRDRWLRVLSPFA
PDYIQRSLFHRKGINEESCFSFLRFIDISPAEMANLMLQGLLARWLALFL
SLKASYRLHQLRSWGAPEGESHQRYLRNKDFLLGVNFPLSFPNLCSCPLL
KSLVFSSHCKAVSGYSDQVVHQRRSATSSLRRCLLTELPSFLCVASPRVT
AVPLDSYCNDRSAEYERRVLKEGGSLAAKQCLLNGAPELAADWLNRRSQF
FPEPAGGLWSIRPQNGWSFIRIPGKESLITDSGKLYALDVLLTRLKSQGH
RVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVADFQNRND
IFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQ
VTVYRLICKGTIEERILQRAKEKSEIQRMVIS
Ligand information
>7zi4 Chain Y (length=158) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatcccgagtacatgcacaggatgtatatatctgacacgtgcctg
gagactagggagtaatccccttggcggttaaaacgcgggggacagcgcgt
acgtgcgtttaagcggtgctagagctgtctacgaccaattgagcggcctc
ggcaccgg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7zi4 Cryo-EM structure of the human INO80 complex bound to a WT nucleosome
Resolution3.2 Å
Binding residue
(original residue number in PDB)		S662 R664 W1198
Binding residue
(residue number reindexed from 1)		S137 R139 W630
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042393 histone binding
GO:0043014 alpha-tubulin binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0006275 regulation of DNA replication
GO:0006281 DNA repair
GO:0006282 regulation of DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006338 chromatin remodeling
GO:0006351 DNA-templated transcription
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0030307 positive regulation of cell growth
GO:0033044 regulation of chromosome organization
GO:0034644 cellular response to UV
GO:0045739 positive regulation of DNA repair
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045995 regulation of embryonic development
GO:0051225 spindle assembly
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0060382 regulation of DNA strand elongation
GO:0070914 UV-damage excision repair
GO:0071479 cellular response to ionizing radiation
GO:1904507 positive regulation of telomere maintenance in response to DNA damage
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0016604 nuclear body
GO:0031011 Ino80 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zi4, PDBe:7zi4, PDBj:7zi4
PDBsum7zi4
PubMed
UniProtQ9ULG1|INO80_HUMAN Chromatin-remodeling ATPase INO80 (Gene Name=INO80)

[Back to BioLiP]