Structure of PDB 7yo0 Chain G Binding Site BS02

Receptor Information
>7yo0 Chain G (length=882) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWEVGWMTSVKDWA
GVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQ
IDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNR
SWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAG
FIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGR
LFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHI
TLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFY
QGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYH
PKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFP
TVCELCFVKLKLLMISRILINPGNGTLGFFIASDAKEVKRAFFYCKKKYD
STGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNL
VMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRA
DLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDTTGV
NIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR
CRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLST
PSQCTKRYVITNPPYEFELVPTDLIFCLMQFD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7yo0 Chain G Residue 1103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yo0 Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex
Resolution3.6 Å
Binding residue
(original residue number in PDB)		D367 R514 S533 E535 S600
Binding residue
(residue number reindexed from 1)		D316 R463 S482 E484 S533
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yo0, PDBe:7yo0, PDBj:7yo0
PDBsum7yo0
PubMed
UniProtQ12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)

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